Design, monitoring, and analysis of sequential clinical trials
![[R logo]](../../../doc/html/Rlogo.svg)
![[Up]](../../../doc/html/left.jpg)
![[Top]](../../../doc/html/up.jpg)
Documentation for package ‘RCTdesign’ version 1.3
Help Pages
| RCTdesign-package | Design, evaluation, monitoring, and analysis of randomized clinical trials. |
-- A --
| all.equal.seqDesign | 'all.equal' method for '"seqDesign"' objects |
| as.seqBoundary | Create or test for a SeqTrial Boundary Object |
| as.seqDesign | Group Sequential Design |
| as.seqScale | Create a "seqScale" object |
-- C --
| changeSeqScale | Change Boundary Scale for Sequential Statistics |
| checkSeqBoundary | Utility Functions Related to "seqBoundary" Objects |
| checkSeqScale | Checks if display scale is valid |
| confidenceInterval | Confidence interval |
| confidenceLevel | Extract group sequential design parameters from RCTdesign objects. |
| confidenceLevel.seqDesign | Extract group sequential design parameters from RCTdesign objects. |
| confidenceLevel.seqHypothesis | Extract group sequential design parameters from RCTdesign objects. |
-- D --
| dexp.pcws | Piecewise Exponential Probability Distribution |
| dMeanSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
| dSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
| dunif.pcws | Piecewise Uniform Probability Distribution |
| dweibull.pcws | Piecewise Weibull Probability Distribution |
| dZSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
-- G --
| getDesigns | Retrieve Designs and Names from RCTdesign Objects |
| getListNames | Retrieve Designs Names from List of RCTdesign Objects |
-- H --
| Hexp.pcws | Piecewise Exponential Probability Distribution |
| hexp.pcws | Piecewise Exponential Probability Distribution |
| Hweibull.pcws | Piecewise Weibull Probability Distribution |
| hweibull.pcws | Piecewise Weibull Probability Distribution |
-- I --
| integCondSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
| is.seqBoundary | Create or test for a SeqTrial Boundary Object |
| is.seqDesign | Group Sequential Design |
| is.seqFixDesign | Create a Fixed Sample Design |
| is.seqHypothesis | Hypotheses Object |
| is.seqModel | Group Sequential Design Model Object |
| is.seqMonitor | Monitoring of a Clinical Trial |
| is.seqOC | Operating Characteristics Object |
| is.seqOperatingChar | Operating Characteristics Object |
| is.seqScale | Create a "seqScale" object |
-- M --
| meanSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
-- P --
| pexp.pcws | Piecewise Exponential Probability Distribution |
| plot.seqBoundary | Plot a Group Sequential Design |
| plot.seqDesign | Plot a Group Sequential Design |
| plot.seqInference | Plot the Inference for a Group Sequential Design |
| plotexp.pcws | Piecewise Exponential Probability Distribution |
| plotweibull.pcws | Piecewise Weibull Probability Distribution |
| powerTest | Extract group sequential design parameters from RCTdesign objects. |
| powerTest.seqDesign | Extract group sequential design parameters from RCTdesign objects. |
| powerTest.seqHypothesis | Extract group sequential design parameters from RCTdesign objects. |
| print.seqBoundary | Print methods for RCTdesign objects. |
| print.seqDesign | Print methods for RCTdesign objects. |
| print.seqEvaluate | Print methods for RCTdesign objects. |
| print.seqHypothesis | Print methods for RCTdesign objects. |
| print.seqInference | Print methods for RCTdesign objects. |
| print.seqModel | Print methods for RCTdesign objects. |
| print.seqMonitor | Print methods for RCTdesign objects. |
| print.seqOC | Print methods for RCTdesign objects. |
| print.seqOperatingChar | Print methods for RCTdesign objects. |
| print.seqParameters | Print methods for RCTdesign objects. |
| print.seqPHAccrual | Print methods for RCTdesign objects. |
| print.seqPHNSubjects | Print methods for RCTdesign objects. |
| print.seqScale | Create a "seqScale" object |
| pSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
| punif.pcws | Piecewise Uniform Probability Distribution |
| pweibull.pcws | Piecewise Weibull Probability Distribution |
-- Q --
| qexp.pcws | Piecewise Exponential Probability Distribution |
| qSeq | Distribution of Sequential Test Statistics in Group Sequential Trial |
| qunif.pcws | Piecewise Uniform Probability Distribution |
| qweibull.pcws | Piecewise Weibull Probability Distribution |
-- R --
| RCTdesign | Design, evaluation, monitoring, and analysis of randomized clinical trials. |
| RCTfunctionList | List of Functions in RCTdesign |
| RCTversion | Return Versions of all RCTdesign Functions |
| rexp.pcws | Piecewise Exponential Probability Distribution |
| rSeqBinom1 | Simulate Clinical Trials for the Proportions Probability Model |
| rSeqBinom2 | Simulate Clinical Trials for the Proportions Probability Model |
| rSeqBinomial | Simulate Clinical Trials |
| rSeqBinomial | Simulate Clinical Trials for the Proportions Probability Model |
| rSeqGeomMean | Simulate Clinical Trials |
| rSeqGeomMean | Simulate Clinical Trials for the Geometric Mean Probability Model |
| rSeqGeomMean1 | Simulate Clinical Trials for the Geometric Mean Probability Model |
| rSeqGeomMean2 | Simulate Clinical Trials for the Geometric Mean Probability Model |
| rSeqHazard | Simulate Clinical Trials |
| rSeqHazard | Simulate Clinical Trials for the Proportional Hazards Model |
| rSeqMean | Simulate Clinical Trials |
| rSeqMean | Simulate Clinical Trials for the Mean Probability Model |
| rSeqMean1 | Simulate Clinical Trials for the Mean Probability Model |
| rSeqMean2 | Simulate Clinical Trials for the Mean Probability Model |
| rSeqOdds | Simulate Clinical Trials |
| rSeqOdds | Simulate Clinical Trials for the Proportions Probability Model |
| runif.pcws | Piecewise Uniform Probability Distribution |
| rweibull.pcws | Piecewise Weibull Probability Distribution |
-- S --
| sampleSize | Extract group sequential design parameters from RCTdesign objects. |
| sampleSize.seqBoundary | Extract group sequential design parameters from RCTdesign objects. |
| sampleSize.seqDesign | Extract group sequential design parameters from RCTdesign objects. |
| sampleSize.seqParameters | Extract group sequential design parameters from RCTdesign objects. |
| seqBoundary | Create or test for a SeqTrial Boundary Object |
| seqBoundary.object | Group Sequential Boundary Object |
| seqBoundaryLabels | Utility Functions Related to "seqBoundary" Objects |
| seqBoundaryReplaceNA | Utility Functions Related to "seqBoundary" Objects |
| seqBoundaryTimeValue | Utility Functions Related to "seqBoundary" Objects |
| seqCalcAccrTime | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcATST | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcHaz(surv, times | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcHazFromSurvTime | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcNSubj | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcSS | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcST | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcSurv(haz, times | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCalcSurvTimeFromHaz | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqCheckExpMeanJ2 | Validation of Operating Characteristics Computed Using Numerical Integration |
| seqCheckOC | Validation of Operating Characteristics Computed Using Numerical Integration |
| seqDesign | Group Sequential Design |
| seqDesign.boundaryShape | seqDesign Boundary Shape Details |
| seqDesign.multiple.arms | seqDesign multiple arms trials (arms>2) |
| seqDesign.object | Group Sequential Design Object |
| seqDesign.probabilityModel | seqDesign Probability Model Details |
| seqDesign.specialFamilies | seqDesign Special Families |
| seqDesign.testSpecifications | seqDesign Test Specification Details |
| seqDF.Boundary | Utility Functions Related to "seqBoundary" Objects |
| seqEvaluate | Complete evaluation of a group sequential design. |
| seqEvaluateOneSided | Complete evaluation of a group sequential design. |
| seqEvaluateTwoSided | Complete evaluation of a group sequential design. |
| seqExactBinomial | Computation of Operating Characteristics for a Clinical Trial Design |
| seqExtract | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqDesign | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqEvaluate | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqHypothesis | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqInference | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqModel | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqOC | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqOperatingChar | Extract group sequential design parameters from RCTdesign objects. |
| seqExtract.seqParameters | Extract group sequential design parameters from RCTdesign objects. |
| seqFixDesign | Create a Fixed Sample Design |
| seqFixDesign.seqDesign | Create a Fixed Sample Design |
| seqFixDesign.seqOC | Create a Fixed Sample Design |
| seqFixDesign.seqOperatingChar | Create a Fixed Sample Design |
| seqGetDropout | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqGetEntry | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqGetEvent | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqHypothesis.object | Hypotheses Object |
| seqInference | Inference for a Group Sequential Hypothesis Test |
| seqInference.object | Inference Object |
| seqModel.object | Group Sequential Design Model Object |
| seqMonitor | Monitoring of a Clinical Trial |
| seqOC | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOC.object | Operating Characteristics Object |
| seqOCExact | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOCSimulate | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOperatingChar | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOperatingChar.default | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOperatingChar.Karms | Computation of Operating Characteristics for a Clinical Trial Design |
| seqOperatingChar.object | Operating Characteristics Object |
| seqOperatingChar.seqDesign | Computation of Operating Characteristics for a Clinical Trial Design |
| seqParameters.object | Parameters for Group Sequential Design Object |
| seqPHAccrual | Accrual characteristics for a hazards model design |
| seqPHNSubjects | Accrual and followup requirements for hazards model designs |
| seqPHSubjects | Proportional Hazards Sample Size |
| seqPlotASN | Plot ASN and Sample Size Quantile Curves |
| seqPlotBoundary | Plot a Group Sequential Design |
| seqPlotInference | Plot the Inference for a Group Sequential Design |
| seqPlotPHNSubjects | Plots of Accrual of Subjects in Hazards Probability Model |
| seqPlotPower | Plot a Power Curve |
| seqPlotStopProb | Stopping Probabilites |
| seqQuantToHazExp | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqQuantToParWeib | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqSameProbModel | Group Sequential Design Model Object |
| seqScale | Create a "seqScale" object |
| seqScale.object | Group Sequential Design Scale Object |
| seqScaleLabel | Create a "seqScale" object |
| seqScalePP | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqSimDropout | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqSimEntry | Utility Functions for Modeling Accrual in Time to Event Analyses |
| seqSimEvent | Utility Functions for Modeling Accrual in Time to Event Analyses |
| survCalc | Miscellaneous calculations related to survival distributions |
-- U --
| update.seqPHAccrual | Accrual characteristics for a hazards model design |